COURSES, REPORTS, GATHERINGS
can be used for much more than just Southern blotsthey are
also powerful tools for the diagnosis and treatment of disease.
But more exotic biomedical research applications may call for more
exotic radionuclides. NIH scientists can now request specialand
more mundaneisotopes for their research from the U.S. Department
of Energy (DOE).
Some of the
clinically important isotopes, such as those used for positron emission
tomography scanners, are so short-lived that they must be produced
on the NIH campus. The DOE produces and distributes diagnostic and
therapeutic isotopes with half-lives longer than about three days.
The DOE distributes
four classes of isotopes. Stable isotopes, such as helium-3, and
"essentially stable," long-lived radioactive isotopes, such as aluminum-26,
are sold from inventory. The final two categories, research and
commercial isotopes, have much shorter half-lives2.6 days
to yearsand are produced as needed.
is an interesting example. This isotope, with a half-life of 10
days, is produced from fissile, Cold-War legacy uranium-233. An
a-emitter, Ac-225 shows promise as a
DOE builds and maintains unique facilities to produce isotopes such
as Ac-225 that simply aren't available anywhere else, it does not
have the funds to produce isotopes that do not have buyers. The
agency has thus established a peer-review process, called the Nuclear
Energy Protocol for Research Isotopes (NEPRI), to determine which
research isotopes will be produced in a given fiscal year.
process begins in February with the distribution of pre-applications
to research, medical, and commercial customers. These forms are
due in late spring, when they are peer-reviewed. The final list
of isotopes to be produced in a subsequent fiscal year is made public
by late summer, and orders are accepted until the end of September
for the next fiscal year. (Scientists have until September 30 to
place their orders for fiscal year 2004.) Payment must be made 30
days before the start of production to cover production and isolation
sheet with contact information and lists of isotopes available
in FY2004 can be downloaded.
document also contains information on how to request isotopes for
For a glimpse
of this years pre-application
form, see this website.
NEW KIND OF NAPSTER:
FREE ONLINE REPORT
interested in the full text of the latest outside effort to evaluate
the structure of NIHentitled Enhancing the Vitality of
the National Institutes of Health: Organizational Change to Meet
New Challengesmay now "read it free online."
July 29, the report was prepared by a blue-ribbon panel convened
by the National Research Council and the Institute of Medicine in
response to a congressional mandate.
After a year-long
study that focused on whether the proliferation of institutes at
NIH is or may become an impediment to NIHs ability to respond
efficiently to the countrys research needs, the panel declined
to recommend the "widespread consolidation" of institutes
panel suggested establishment of a formal process to review and
act on any proposals for IC restructuringand urged that two
particular mergers be first in line for consideration: NIDA
with NIAAA and NIGMS
had suggestions for the enhancement of clinical research, high-risk
research, and trans-institute research initiatives consistent with
the "road map" plans already under development at NIH
(see "Cartographers Draft NIH Research
include taking special care not to outsource administrative functions
that are deeply tied to scientific functions, reconsidering NCIs
special legislative status, and establishing "term limits"
for institute directors and the NIH director.
FESTIVAL STRIKES GOLD(EN
ANNIVERSARY OF THE CLINICAL
Research Festival will kick
off Tuesday October 14 with
a symposium extravagantlyand correctlytitled "The
Past, Present, and Future of Clinical Research" (8:305:30,
who will trace the progress in the major clinical realms are the
people who effected that progress in the last century and continue
to carry the work into this one.
or current NIH investigators, the speakers are (in order of appearance)
Vincent DeVita, Tom
Rosenberg, Eugene Braunwald, Elizabeth
Nabel, Steve Paul, Henry
McFarland, French Anderson, Allen
Spiegel, Elizabeth Neufeld, Francis
Fauci, and John
matter spans cancer therapeutics, cardiovascular disease, neuroscience,
the molecular basis of disease, and infectious diseases.
Festival runs from the 14th through the 17th. Music and food will
refresh festival goers as they immerse themselves in the scientific
offerings of 12 minisymposia and hundreds of posters. There will
also be exhibits of intramural resources and commercial suppliersand,
of course, the Job Fair for NIH postdocs and clinical fellows.
sessions, 10:30 a.m.12:00 p.m. and 2:00 p.m.3:30 p.m.,
will be held Wednesday, October 15,
The six simultaneous
morning symposia are on host response to infectious diseases, the
"new omics" in the molecular epidemiology of chronic diseases,
protein-protein interactions, virus entry-virus receptor interactions,
programmed cell death, and interconnection of hormones, bone, and
symposia address genome instability, bioinformatics from bench to
bedside, negative regulation of immune responses, bringing genetics
to the public, macromolecular complexes and assemblies, and interfacing
the physical and biological sciences.
festival is co-chaired by Joseph
Fraumeni, director of the Division of Cancer Epidemiology and
Genetics, NCI, and Robert
Desimone, NIMH scientific director.
The full festival
schedule is here.
OF CLINICAL RESEARCH
deadline for registering for the 20032004 course on "Introduction
to the Principles and Practice of Clinical Research" is October
3. The course runs from October
20, 2003, to February 24, 2004, and is held on the NIH
campus Monday and Tuesday evenings from 5:00 p.m. to approximately
6:30 p.m. The course is free of charge, but textbook purchase is
required. A certificate will be awarded upon successful completion
of the course, including a final exam.
information or to register, go to this website
or call the Office of Clinical Research Training and Medical
Education at 301-496-9425. An e-mail confirmation will be sent to
those accepted into the program.
accommodations, call (301) 496-9425, 8:30 a.m.5:00 p.m., at
least seven business days before the event.
course objectives are:
To understand the basic epidemiologic methods involved in clinical
To be grounded in the principles of clinical research ethics and
the legal issues and regulations involved in human subjects research,
including the role of IRBs in clinical research.
To become familiar with the principles and issues involved in monitoring
To understand the infrastructure required in the conduct of clinical
research and the steps involved in developing and funding research
is aimed at physicians and other health professionals training for
a career in clinical research. Interested persons are strongly encouraged
to take a course in biostatistics such as STAT 200 or STAT 500,
currently offered at the FAES
(see "Its Not Too Late!").
NIH/FAES is accredited by the Accreditation Council for Continuing
the answer to any of the following questions is "yes,"
CIVIL, the NIH team of experts that promotes civil behavior in the
NIH workplace, is available to help sort through the issues and
determine the next steps to take.
Are you or someone you know having difficulty managing anger at
Are you concerned about how to respond to behavior at work that
is less than civiland possibly even intimidating, harassing,
or verbally or physically threatening?
Are family or other personal disputes affecting your ability to
think clearly and be productive at work, or are you worried that
family members or others with hostile attitudes or behavior may
make unwanted visits to the worksite to see you?
Do you believe that you or any of your colleagues are experiencing
overwhelming feelings of depression or thoughts of suicide?
Have you seen other behavior changes (or behaviors) in yourself
or others at work that are cause for worry?
be reached at this phone number: C-I-V-I-L, or 2-4845; TTY
at 301-402-9499. ANYONE can call CIVIL. For more info, either call
or go to this website.
you think you or others are in IMMEDIATE danger, always call 911
first, if on campus, and 9-911, if off-campus.
NOT TOO LATE
a $5 late fee, late registration for the FAES
(Foundation for Advanced Education in the Sciences) Graduate School
at NIH is being accepted through October
9. $10 will enable late registration through October
24but that is the last possible day.
The FAES 200304
course catalog is available on line as a PDF file at the FAES
website.. The hard copy can be picked up at the FAES Bookstore
(CC/Building 10, B1 level) and at the FAES Graduate School (One
Cloister Court/Building 60, Suite 230). Required texts are also
available at the bookstore.
For more info,
call 301-496-7976. FAES could use more classroom space; suggestions
TO ONLINE CATALYST
online version of The NIH Catalyst can be found here
is accessible to all computers within the NIH network.
To be notified
when each new issue hits cyberspace and of its approximate contents,
subscribe to the Catalyst-L listserve. Send an e-mail message to
catalyst-L Your Name.
ONE PIN DOES IT
October 1, 2003, NIH employees
will use Employee
Express, an automated system that provides access 24/7, for
management of the following transactions:
Tax withholding (federal & state exemptions/amount)
Direct deposit/financial allotment changes
Home aaddress change
Federal employee health benefit plan/enrollment changes (during
TSP percentage of salary deductions (during open season)
be made to benefits information anywhere and any time.
To find out
how you can get your PIN and to learn more about Employee Express,
visit the website.
HOUSE, OPEN CALL:
RFB&D NEEDS SCIENTISTS
a nonprofit organization that provides recorded textbooks for blind
and dyslexic students, has a much greater demand for high-level
science texts than it can fulfill. Its most critical need is
for readers who are specialists such as chemists, physicists, doctors,
computer scientists, and mathematicians.
If you have
a background in any of these areas or a related field, come to an
RFB&D Open House: Wednesday, October
8, Building 31, Conference Room 10, 10:00 a.m.2:00
has a recording space at NIH, for the convenience of scientists
and medical experts who can record college and postgraduate level
science texts. All necessary training on recording equipment is
provided. A 1-hour per week commitment for a minimum of six months
For more info,
stop by the open house or contact Sarah Scully by e-mail
or at (202) 244-8990.
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