by Jack Schmidt, Ph.D., FIC

Over the next few months, NIH will be the research venue for 18 participants in the Fogarty International Center's (FIC's) Scholars-in-Residence Program - the largest number of Fogarty scholars on campus at any one time since the program began 27 years ago. The scholars will conduct collaborative research with intramural scientists, present lectures, participate in seminars, and get involved in the activities of Interinstitute Interest Groups.

Ruth Arnon,
March 1 - July 1, 1996

Vice-president of the Weizmann Institute of Science in Rehovot, Israel, Arnon is a distinguished immunologist and parasitologist whose research on antigens and synthetic peptides has had a major impact. Of particular note is her demonstration that antibodies to peptides of biologically active proteins can be identified, synthesized, and used both as immunogens and antigens. She is a pioneer in the development of vaccines that use synthetic peptides. Arnon was nominated by William Paul, NIAID.

Melvin Cohn,
March 1 - June 30, 1996

A resident fellow of the Salk Institute for Biological Studies in La Jolla, Calif., Cohn is known for his important contributions to immunologic theory, especially for adding to the understanding of the genetic basis of immunoglobulin diversification and for proposing the two-signal model of lymphocyte activation. Currently, Cohn is working on computer-generated models of immunological responsiveness. Cohn was nominated by Polly Matzinger, NIAID.

Madhav Deo,
April 1 - Sept. 30, 1996

Most recently the director of the Cancer Research Institute at the Tata Memorial Center in Bombay, Deo is one of India's leading biomedical scientists, specializing in the fields of mycobacterial immunology, cancer biology, and protein-calorie malnutrition. His work on an anti-leprosy vaccine, on growth factors and oncogenes in oral cancer, and on the pathogenesis of kwashiorkor has received wide attention. Deo was nominated by Ian Magrath, NCI.

Guy De Thé,
March 18 - June 30, 1996

De Thé is director of the Unit on the Epidemiology of Oncogenic Viruses at the Pasteur Institute in Paris. He has gained recognition primarily as the result of three major studies: demonstration of the etiological role of Epstein-Barr virus (EBV) in Burkitt's lymphoma in Africa; establishment of a close association of EBV with nasopharyngeal carcinoma in North Africa and China; and demonstration of a possible causal relationship between HTLV-1 and tropical spastic paraparesis, a neuromyelopathy endemic in the French West Indies. De Thé was nominated by William Blattner, NCI.

Alan Fersht,
March 1 - May 30, 1996

A professor of organic chemistry at the University of Cambridge in England and head of the Medical Research Council's protein function and design unit, Fersht is widely regarded as the leading practitioner in studies of protein folding and of the relationship between structure and function by means of site-directed mutagenesis. He has used molecular biology tools to study protein stability and transition states in protein folding, particularly with the small, globular protein, barnase as a model. Fersht was nominated by Marius Clore, Angela Gronenborn, and Ad Bax, NIDDK.

Jean Garnier,
April 15 - June 15, 1996

Director of research at the Protein Engineering Unit of the National Institute of Agronomic Research in Jouy-en-Josas, France, Garnier is a world-renowned expert on protein folding and protein-structure prediction. More broadly, he is widely published in the areas of thermodynamics, chemical kinetics, mechanisms of enzyme action, and X-ray-crystallographic-structure determination. Garnier was nominated by David Rodbard, DCRT.

Peter Gruss,
April 1 - July 31, 1996

Gruss, chief of molecular cell biology at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, is a leader in studies of homeobox genes and the molecular biology of mammalian development, particularly in the burgeoning field of the molecular embryology of the mouse. His research on mechanisms that control pattern formation in embryogenesis, organogenesis, and cell differentiation has been seminal to work in this field. Gruss was nominated by Heiner Westphal, NICHD.

Davor Solter,
Dec. 28, 1995 - April 30, 1996

Head of the Department of Developmental Biology at the Max Planck Institute of Immunobiology in Freiburg, Germany, Solter has been in the forefront of research in mammalian development for many years. He defined the mechanisms that underlie the development of teratocarcinoma from normal embryos and the role of cell-surface molecules in preimplantation development. His research was largely responsible for establishing the concept of genomic imprinting, a process that marks genes in such a way that their expression after fertilization is entirely regulated by the gamete of origin. Solter was nominated by Arthur Levine, NICHD.

Peter Wolynes,
April 20 - May 20, 1996

A professor of chemistry, physics, and biophysics at the University of Illinois, Wolynes is widely regarded as the premier theorist in the study of chemical dynamics in the condensed phase. To investigate the effects of the environment on the rates of chemical reactions, he developed the first successful Monte Carlo methods for simulating real-time quantum mechanics, and he applied these to electron-transfer processes in proteins. Recently, Wolynes has focused his work on the application of statistical physics to studies of protein folding and predictions of the three-dimensional structure of proteins. Wolynes was nominated by William Eaton, Attila Szabo, and Robert Zwanzig, NIDDK.

Hans Zachau,
Feb. 11 - April 20, 1996

Zachau, co-director of the University of Munich's Institute for Physiological Chemistry in Germany, is one of Europe's most distinguished molecular biologists. He played a crucial role in elucidating the secondary structure of tRNAs and the biochemical mechanisms involved in their coupling to amino acids. His main recent interest has been in the organization of immunoglobulin genes within the mouse and human genomes - work that has provided valuable information on the generation of antibody diversity. Zachau was nominated by Gary Felsenfeld, NIDDK.

Making Connections

To arrange to meet any of the Fogarty scholars or for more information on the scholars' activities, contact Jack Schmidt, director of FIC's Division of International Advanced Studies (phone: 496-4161; fax; 496-8496; e-mail: schmidtj@box-s.nih.gov). Other scholars who will be here during the spring and summer and whose profiles have previously appeared in The NIH Catalyst (March-April 1995 issue) include:

Yadin Dudai May 1 - Aug. 30, 1996
Benjamin Geiger June 15 - Sept. 15, 1996
Illana Gozes July 10, 1995 - July 9, 1996
Tasuku Honjo July 10 - Aug. 31, 1996
Koji Kimata July 1 - Sept. 30, 1996
Yuan Chuan Lee March 1 - July 1, 1996
Suryanarayan Ramachandran June 15, 1995 - June 14, 1996
Eugene Rosenberg July 1 - Oct. 1, 1996

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