T H E N I H C A T A L Y S T | J U L Y A U G U S T 2006 |
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Commentary
PIGMENT CELL INTEREST GROUPA PORTRAIT
When
an immigration officer at Dulles Airport recently asked a French graduate student
what she was working on at NIH, she happily responded: "Studying the biology
of pigment cells! The officer shot back: "Do we really need French people
for doing this?"
One might as well ask, do we really need pigment cell research
at NIH? The answer is a resounding "Yes!" Pigment cells are not
only for the fashion-conscious. We need them in the eye for vision. We need
themand this may come as a surprisein the inner ear for hearing.
Their abnormalities can point to systemic disorders or lead
to life-threatening melanomas. They are model cells for a host of basic studiesin
developmental biology, cell biology, immunology, genetics, biochemistry, and
more. They have yielded insights into G-coupled signaling pathways, intracellular
transport, cell-lineage specification, and malignant transformation.
Pigment mutations in mice, which occur in more than 100
different genes, were among the first to be mapped in the genome.
In short, pigment cells are important.
But what exactly are pigment
cells? There are many types and many different colors in animals. The major
type in mammals is the melanocyte, which is derived from the neural crest. Its
pigmentmelaninis a biopolymer that is synthesized through a series
of catalytic steps starting with the conversion of the amino acid tyrosine to
dihydroxyphenylalanine by a copper-binding enzyme called tyrosinase.
Melanin comes in two versions:
black eumelanin and yellow pheomelanin. Both versions are made in membrane-bound
intracellular organelles called melanosomes.
Not every cell that contains
melanosomes is a melanocyte, however, because melanocytes can transfer their
melanosomes to other cell types that are not capable of producing melanin themselves.
In human skin, for instance, melanosomes are transferred from melanocytes to
keratinocytes and into hair shafts; in birds, they are found in feathers.
Melanocytes are present
in the iris, which serves as an aperture to regulate the depth of focus and
the amount of light that enters the eye. A reduction in iris pigmentation leads
to blurred vision. Melanocytes are also found in the choroid behind the retina,
where they serve to block the passage of light to deeper tissues.
Between retina and choroid,
there is yet another layer of pigment cells, called the retinal pigment epithelium,
that regulates the development of the eye in the embryo and the physiology of
photoreceptor cells in the adult.
In the inner ear of mammals,
melanocytes are found in a portion of the wall of the cochlear duct, where they
regulate the ionic composition of the endolymph and ensure that auditory hair
cells function normally.
Typically, there are three possible consequences of melanocyte
misconduct: Their numbers can change, the amount and quality of pigment can
change, or the cells can become malignant. Malignant potential is what makes
melanocyte pathology a major health burden for humans. In the United States
alone, more than 60,000 new melanoma cases are projected to arise this yearyet
preventing melanoma is entirely feasible. For more information on melanoma,
go to
Over the years, the NIH Intramural Research Program has
become one of the premier centers for pigment cell research worldwide. At least
six institutes have active programs in this field, ranging from developmental
biology to organelle and melanin biosynthesis to tumor biology, immunology,
and epidemiology.
Last year, NIH hosted the International Pigment Cell Congress,
chaired by Vincent
Hearing, NCI. The meeting focused on human pigmentary diseases and attracted
more than 400 attendees from all over the world.
In 2001 and again in 2004, two consecutive meetings of the
Development Group of the International Federation of Pigment Cell Societies
met on campus at the Cloisters. Co-chaired by NHGRI's William
Pavan, they each drew more than 50 participants and generated a great deal
of excitement.
The Pigment
Cell Interest Group enables dynamic interactions among many labs both inside
and outside NIH. This active group usually meets on the third Thursday of the
month at 12:30 in the conference room of Building 49.
Each month, one of the many member labs presents its hottest
results and discusses future approaches. In addition, students and postdocs
have the opportunity to present practice talks for upcoming national or international
meetings.
We welcome new members. Find out more about this groupand
join upright here.
Senior Investigator
Laboratory of Developmental Neurogenetics
NINDS
NEW
WEBSITE OFFERS PATHWAYS
TO TRANS-NIH IMMUNOLOGY RESEARCH A
new website that provides a single point of access to campus-wide intramural
immunology research is now available at This
site is the fruit of more than a year's work by the NIH immunology steering
committee. It contains n A
searchable faculty directory of more than 150 immunology labs at NIH n A
history of immunology in the intramural research program n Useful links, including publicly accessible webcast archives of NIH immunology research seminars by invited and internal speakers dating back four years. n |