T H E   N I H    C A T A L Y S T     J U L Y  –  A U G U S T   2001

MAJOR SHARED AND MULTI-INSTITUTE RESEARCH RESOURCES

IN THE INTRAMURAL RESEARCH PROGRAM

Research Resource
Location

Governance/Contact/Participants
Research Services/Review
LEGACY RESOURCES—AVAILABLE TO ALL INSTITUTES AND CENTERS
Veterinary Resources Program (VRP) Building 14–28 complex; Bethesda; Poolesville

Office of Research Services (ORS).
M. Eckhaus, acting director <http://www.nih.gov/od/ors/dirs/vrp/vrphome.htm>

Veterinary services (surgery, radiology, pharmacy, nutrition, rodent genetic repository, animal behavior and enrichment); animal husbandry, procurement, quarantine, and health surveillance; diagnostics (pathology, bacteriology, parasitology, serology); embryo cryopreservation and rederivation

Review: Shared Resources Subcommittee (SRS), ICs
Bioengineering (Division of Bioengineering and Physical Sciences Building 13 ORS.
R. Leapman, acting director <http://www.nih.gov/od/ors/dbeps/index.htm>

Drug delivery, molecular interactions, image analysis, instrumentation, supramolecular structure, ultramicroscopic immunochemistry

Review: SRS, ICs
Scientific Equipment and Instrumentation Branch Building 13 ORS.
J. Robbins, chief
<http://seib.od.nih.gov>		 Maintain scientific equipment and computers; design and fabricate custom instruments; lease and sell scientific and medical equipment
Medical Arts and Photography Branch Building 10, B2 level ORS.
L. Canady, chief <http://www.nih.gov/od/ors/dirs/mapb/mapbhome.htm>		 Medical illustration, photomicroscopy, photomacroscopy, scientific posters
NIH Library Building 10 ORS.
S. Grefsheim, director
<http://nihlibrary.nih.gov>

Full-service library, including electronic journals, electronic document desktop delivery and translations

Review: Users committee, ICs
Center for Information Technology (CIT) Division of Computational Bioscience Building 12 complex CIT.
R. Martino, acting director
<http://www.cit.nih.gov/science.html

Image processing, bioinformatics, computational methods and algorithms, computer engineering, bioscience, molecular modeling, mathematical and statistical computing

Review: SRS, ICs
MULTI-INSTITUTE SHARED SERVICES
NIH Magnetic Resonance Imaging Facility Building 10, In Vivo NMR Center

Lead IC: NINDS.
A. Koretsky, director, and steering committee.

Participants: All ICs but NIEHS

Human and animal MRI; other IC MRI instruments available

Review: SRS, ICs, steering committee

Mouse Imaging Facility

 Building 10, In Vivo NMR Center

Lead ICs: NINDS, NHLBI.
A. Koretsky, director, and steering committee.

Participants: All ICs but NIEHS are paid charter members

Mouse radiologic imaging (from fall 2001); 7T rodent MRI, microCT, high-frequency ultrasound, laser Doppler

Review: SRS, ICs, steering committee
Structural Biology NMR Buildings 5, 6A, and 50

Lead ICs: NINDS, A. Bax
NHLBI, J. Ferretti
NIDCR, D. Torchia

Also: NCI

Molecular structural imaging: 500MHz cryoprobe NMR spectrometer; 800MHz NMR spectrometer; now shopping for 900 MHz NMR spectrometer

Review: ICs
Center for Inherited Disease Research Bayview Research Campus, Baltimore

Lead contracting IC: NHGRI.
D. Valle, Johns Hopkins University PI.
Access Committee: <http://www.cidr.jhmi.edu>

Any IC may request service

Genotyping, DNA banking, statistical genetics consultation, mouse genotyping.

Review: CIDR Access Committee (Jerry Roberts, NHGRI)
NIH Intramural Sequencing Center Advanced Technology Center, Gaithersburg, MD

Lead IC: NHGRI.
E. Green, director; Multi-Institute Access Review Committee: <http://www.nisc.nih.gov>

Participants: NHGRI, NCBI, NIDCD, NIAAA, NIDA, NHLBI, NIDDK, NICHD, NEI, NIAMS, NINDS, NIDCR, NIEHS, NIMH

Production-scale DNA sequencing, assimilation and analysis of sequence data, acquisition and development of new sequencing chemistry, instrumentation, sequence analysis software.

Review: Users Committee
Microarray services

1. Multiple sites

2. Building 12A

1. NHGRI, NCI, NIA

2. CIT (P. Munson, J. Powell), with contributions from NINDS, CC, NHLBI, NIAID, NCI

1. Chips prepared by special arrangement. Review: ICs

2. Analysis, database storage and retrieval, bioinformatics services for microarray data. Review: ICs
Protein Expression Lab Building 6B, Room 1B130

Lead IC: NIAMS
P. Wingfield, chief <http://www.nih.gov/niams/about/irp/pelhome.htm>

Participants: NHGRI, NCBI, NIDCD, NIAAA, NIDA, NHLBI, NIDDK, NICHD, NEI, NIAMS, NINDS, NIDCR, NIEHS, NIMH

Expression, purification, and structural characterization of HIV and HIV-related proteins via a variety of techniques; protein EXE software; supply HIV-1 protease

Review: IATAP, ICs
Biotechnology unit (pilot plant) Building 6, Room B1–33

Lead IC: NIDDK
J. Shiloach, director <http://www.niddk.nih.gov/intram/people/jshiloac.htm>

Major client: NICHD
Other recent users: NEI, NCI, NHLBI, NIDCR. Any IC may request service

Production and purification of biological material, especially scale-up protein production and purification

Review: BSC, ICs
Mass spectroscopy Building 8A, Room B2A19–21; Building 10

Lead ICs: NIDDK, NHLBI, NIMH, NIAID, NINDS
<http://proteome.nih.gov/shared.html>

advisory group

QTOF–LCMS; high-resolution magnetic sector; MALDI, LC-ion trap

Review: BSC, ICs
Bioinformatics support Building 38A, NCBI

Lead IC: NCBI

Any IC may request training

Extended training in bioinformatics for intramural investigators

Review: ICs
Synchrotrons:
1. Advanced photon source
2. National synchrotron light source		 1. Argonne National Lab
2. Brookhaven National Lab		 DOE
Lead IC: NCI
Major Users: NIDDK, NIEHS, NIAID, NHLBI
1. <http://www.aps.anl.gov>
2.<http://nslsweb.nsls.bnl.gov/nsls/Default.htm> 		1. High-brilliance X-ray beams
2. Intense focused beamlines throughout the spectrum
Integrative Neural Immune Program Multiple locations NIMH, NINDS, NCI, NIAID, NIAMS, NIA
Esther Sternberg, director		 Lecture series, conferences, workshops, retreat; training that bridges neuroscience and immunology; cyberlab to oversee virtual cores
MULTI-INSTITUTE FACILITIES
Warren Grant Magnuson Clinical Center Building 10/future Clinical Research Center

Board of Governors
John Gallin, director <http://www.cc.nih.gov/>

Access to the Clinical Center is available to all ICs

Research hospital that accommodates 300 inpatients and outpatients and provides comprehensive services and facilities in support of clinical research sponsored by the ICs

Review: Joint Commission on Accreditation of Healthcare Organizations, BSC
Advisory: CC Research Steering Committee, CC Board of Governors
Neuroscience Center Site of Buildings 35 and 36 NINDS, NIMH, NEI, NIDA, NIAAA, NIA
Also NIDCR, NHGRI, and NICHD

Neuroscience research

Review: BSCs, ICs
Vaccine Research Center Building 40

NIAID, NCI, OAR

Gary Nabel, directror
<http://www.niaid.nih.gov/vrc/default.htm

Comprehensive HIV (and eventually other) vaccine research, development, and testing

Review: BSC, ICs
Musculoskeletal Center Navy Medical NIAMS (P. Lipsky), NIA, NIDCR, NICHD

Musculoskeletal, cartilage, and orthopedics research

Review: BSC, ICs

 

Return to Table of Contents