A WORLD OF EXPERTISE:
NIH'S RECORD CROP OF FOGARTY SCHOLARS
Over the next few months, NIH will be the research venue for 18 participants in the Fogarty International
Center's (FIC's) Scholars-in-Residence Program - the largest number of Fogarty scholars on campus at any one
time since the program began 27 years ago. The scholars will conduct collaborative research with intramural
scientists, present lectures, participate in seminars, and get involved in the activities of Interinstitute
Interest Groups.
Ruth Arnon,
March 1 - July 1, 1996
Vice-president of the Weizmann Institute of Science in Rehovot, Israel, Arnon is a distinguished
immunologist and parasitologist whose research on antigens and synthetic peptides has had a major impact. Of
particular note is her demonstration that antibodies to peptides of biologically active proteins can be
identified, synthesized, and used both as immunogens and antigens. She is a pioneer in the development of
vaccines that use synthetic peptides. Arnon was nominated by
William Paul, NIAID.
Melvin Cohn,
March 1 - June 30, 1996
A resident fellow of the Salk Institute for Biological Studies in La Jolla, Calif., Cohn is known for his
important contributions to immunologic theory, especially for adding to the understanding of the genetic
basis of immunoglobulin diversification and for proposing the two-signal model of lymphocyte activation.
Currently, Cohn is working on computer-generated models of immunological responsiveness. Cohn was nominated
by Polly Matzinger, NIAID.
Madhav Deo,
April 1 - Sept. 30, 1996
Most recently the director of the Cancer Research Institute at the Tata Memorial Center in Bombay, Deo is
one of India's leading biomedical scientists, specializing in the fields of mycobacterial immunology, cancer
biology, and protein-calorie malnutrition. His work on an anti-leprosy vaccine, on growth factors and
oncogenes in oral cancer, and on the pathogenesis of kwashiorkor has received wide attention. Deo was
nominated by Ian Magrath, NCI.
Guy De Thé,
March 18 - June 30, 1996
De Thé is director of the Unit on the Epidemiology of Oncogenic Viruses at the Pasteur Institute
in Paris. He has gained recognition primarily as the result of three major studies: demonstration of the
etiological role of Epstein-Barr virus (EBV) in Burkitt's lymphoma in Africa; establishment of a close
association of EBV with nasopharyngeal carcinoma in North Africa and China; and demonstration of a possible
causal relationship between HTLV-1 and tropical spastic paraparesis, a neuromyelopathy endemic in the French
West Indies. De Thé was nominated by William Blattner, NCI.
Alan Fersht,
March 1 - May 30, 1996
A professor of organic chemistry at the University of Cambridge in England and head of the Medical
Research Council's protein function and design unit, Fersht is widely regarded as the leading practitioner
in studies of protein folding and of the relationship between structure and function by means of
site-directed mutagenesis. He has used molecular biology tools to study protein stability and transition
states in protein folding, particularly with the small, globular protein, barnase as a model. Fersht was
nominated by Marius Clore,
Angela Gronenborn,
and Ad Bax, NIDDK.
Jean Garnier,
April 15 - June 15, 1996
Director of research at the Protein Engineering Unit of the National Institute of Agronomic Research in
Jouy-en-Josas, France, Garnier is a world-renowned expert on protein folding and protein-structure
prediction. More broadly, he is widely published in the areas of thermodynamics, chemical kinetics,
mechanisms of enzyme action, and X-ray-crystallographic-structure determination. Garnier was nominated by
David Rodbard, DCRT.
Peter Gruss,
April 1 - July 31, 1996
Gruss, chief of molecular cell biology at the Max Planck Institute for Biophysical Chemistry in
Göttingen, Germany, is a leader in studies of homeobox genes and the molecular biology of mammalian
development, particularly in the burgeoning field of the molecular embryology of the mouse. His research on
mechanisms that control pattern formation in embryogenesis, organogenesis, and cell differentiation has been
seminal to work in this field. Gruss was nominated by Heiner Westphal, NICHD.
Davor Solter,
Dec. 28, 1995 - April 30, 1996
Head of the Department of Developmental Biology at the Max Planck Institute of Immunobiology in Freiburg,
Germany, Solter has been in the forefront of research in mammalian development for many years. He defined
the mechanisms that underlie the development of teratocarcinoma from normal embryos and the role of
cell-surface molecules in preimplantation development. His research was largely responsible for establishing
the concept of genomic imprinting, a process that marks genes in such a way that their expression after
fertilization is entirely regulated by the gamete of origin. Solter was nominated by
Arthur Levine, NICHD.
Peter Wolynes,
April 20 - May 20, 1996
A professor of chemistry, physics, and biophysics at the University of Illinois, Wolynes is widely
regarded as the premier theorist in the study of chemical dynamics in the condensed phase. To investigate
the effects of the environment on the rates of chemical reactions, he developed the first successful Monte
Carlo methods for simulating real-time quantum mechanics, and he applied these to electron-transfer
processes in proteins. Recently, Wolynes has focused his work on the application of statistical physics to
studies of protein folding and predictions of the three-dimensional structure of proteins. Wolynes was
nominated by William Eaton,
Attila Szabo,
and Robert Zwanzig, NIDDK.
Hans Zachau,
Feb. 11 - April 20, 1996
Zachau, co-director of the University of Munich's Institute for Physiological Chemistry in Germany, is
one of Europe's most distinguished molecular biologists. He played a crucial role in elucidating the
secondary structure of tRNAs and the biochemical mechanisms involved in their coupling to amino acids. His
main recent interest has been in the organization of immunoglobulin genes within the mouse and human genomes
- work that has provided valuable information on the generation of antibody diversity. Zachau was nominated
by Gary Felsenfeld, NIDDK.
Making Connections
To arrange to meet any of the Fogarty scholars or for more information on the scholars' activities,
contact Jack Schmidt, director of FIC's
Division of International Advanced Studies (phone: 496-4161; fax; 496-8496; e-mail:
schmidtj@box-s.nih.gov). Other scholars who will be here during the
spring and summer and whose profiles have previously appeared in The NIH Catalyst (March-April 1995
issue) include:
| Yadin Dudai |
May 1 - Aug. 30, 1996 |
| Benjamin Geiger |
June 15 - Sept. 15, 1996 |
| Illana Gozes |
July 10, 1995 - July 9, 1996 |
| Tasuku Honjo |
July 10 - Aug. 31, 1996 |
| Koji Kimata |
July 1 - Sept. 30, 1996 |
| Yuan Chuan Lee |
March 1 - July 1, 1996 |
| Suryanarayan Ramachandran |
June 15, 1995 - June 14, 1996 |
| Eugene Rosenberg |
July 1 - Oct. 1, 1996 |
|
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